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|
Name | Choi Yongsoo | Position
(full time/adjunct) |
Full time Professor |
|---|---|---|---|---|
| KIST School Major | Bio-Medical Science and Technology | Division / Center | KIST Gangneung Institute of Natural Products / Natural Product Research Center | |
| yongsoo.choi@kist.re.kr | Telephone | +82-2-033-650-3505 |
Research Field & Research Interest
- My research in natural products is to develop an ubiquitous metaboloimics platform for the identification of bioactive compounds in complex natural product extracts to figure out unrevealed role and/or mechanism of the bioactive compounds in targeted diseases. The metabolomics platform in my research includes a new method development for efficient data production in metabolomics, integration with other multi-OMICS data, interpretation and prediction of metabolites in natural products effective in targeted diseases. This platform can facilitate discovery and development of new drugs, dietary supplements, and natural cosmetics.
Research Project
- Discovery of new molecules associated with rheumatoid arthritis subtypes
- Advanced development in preclinical phase of high functional soybean A63
- Discovery of massive traits and functional resources based on multi-omics including metabolomics and bioactivity of domestic crop core-sets
- Natural products to control colon cancers based on multi-omics data
- Screening and analysis of agricultural genetic resources, rice, soybean and pepper using systematic metabolomics with trait variations for industrial candidates
- Collective functional evaluation of the secondary metabolites and GWAS association
- Screening of western and oriental medicine for the treatment of cancer and autoimmune disease
- Study Group of Natural Product Screening for Antiviral Based on iHTac
- Development of mass spectrometry-based high throughput screening and its application to find active compounds targeted to rheumatoid arthritis
- Advanced development in preclinical phase of high functional soybean A63
- Discovery of massive traits and functional resources based on multi-omics including metabolomics and bioactivity of domestic crop core-sets
- Natural products to control colon cancers based on multi-omics data
- Screening and analysis of agricultural genetic resources, rice, soybean and pepper using systematic metabolomics with trait variations for industrial candidates
- Collective functional evaluation of the secondary metabolites and GWAS association
- Screening of western and oriental medicine for the treatment of cancer and autoimmune disease
- Study Group of Natural Product Screening for Antiviral Based on iHTac
- Development of mass spectrometry-based high throughput screening and its application to find active compounds targeted to rheumatoid arthritis
Paper Publication
No
Title
Journal
Author
Abstract
21
Key hepatic signatures of human and mouse nonalcoholic steatohepatitis: A transcriptome-proteome data meta-analysis
Frontiers in Endocrinology
Jeongjoo, P.; Yongsoo, C.
20
Extract from Black Soybean Cultivar A63 Extract Ameliorates Atopic Dermatitis-like Skin Inflammation in an Oxazolone-Induced Murine Model
Molecules
DORJSEMBE, B.; Nho, C. W.; Yongsoo, C.; Kim, J. C.
19
The soybean cultivar SCEL-1 shows potent anti-photoaging effects in a UV-induced three-dimensional human skin and hairless mouse model
Applied Biological Chemistry
Lee, JW; Peng, L; Jegal, H; Park, NJ; Bong, SK; Lee, JW; Pyo, JJ; Choi, Y; Kim, SN
18
A Novel Competitive Binding Screening Assay Reveals Sennoside B as a Potent Natural Product Inhibitor of TNF-alpha
BIOMEDICINES
Peng, L; Durai, P; Park, K; Pyo, JJ; Choi, Y
17
Dissecting seed pigmentation-associated genomic loci and genes by employing dual approaches of reference-based and k-mer-based GWAS with 438 Glycine accessions
PLOS ONE
Kim, JH; Park, JS; Lee, CY; Jeong, MG; Xu, JL; Choi, Y; Jung, HW; Choi, HK
16
Diosmetin and Its Glycoside, Diosmin, Improve Atopic Dermatitis-Like Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models
BIOMOLECULES & THERAPEUTICS
Park, SA; Bong, SK; Lee, JW; Park, NJ; Choi, Y; Kim, SM; Yang, MH; Kim, YK; Kim, SN
15
Comparative metabolic profiling of cultivated and wild black soybeans reveals distinct metabolic alterations associated with their domestication
FOOD RESEARCH INTERNATIONAL
Hyeon, H; Xu, JL; Kim, JK; Choi, Y
14
Quantification and Distribution Evaluation of Quercetin and Kaempferol in Rat Eyes after Oral Administration of EEDK Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
Bulletin of the Korean Chemical Society
Peng, L; Ahn, HR; Jung, SH; Choi, Y
13
Simultaneous roasting and extraction of green coffee beans by pressurized liquid extraction
FOOD CHEMISTRY
Xu, JL; Kim, TJ; Kim, JK; Choi, Y
12
Metabolic Profiling of Nine Mentha Species and Prediction of Their Antioxidant Properties Using Chemometrics
MOLECULES
Park, YJ; Baek, SA; Choi, Y; Kim, JK; Park, SU
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